More Precise RA Patient Care; New data on the 14-3-3η blood test to help optimize treat-to-target strategies

Simran ChahalNews

At the annual European congress of rheumatology meeting, The European League Against Rheumatism (EULAR), taking place in Amsterdam on June 13th-16th, leading investigators from United States, Israel, and Egypt will present new data on the 14-3-3η blood test. Several of these studies grow the body of evidence of 14-3-3η’s key role as an early diagnostic test that assists with rheumatoid arthritis (RA) patient management along the disease course. As a highlight, one study describes how 14-3-3η levels can assist with monitoring patients on Tofacitinib therapy. 14-3-3η is a modifiable marker of joint damage progression risk, which makes it ideal to track over time for the optimisation of RA treat-to-target strategies to improve clinical and radiographic outcomes. It is expected that 14-3-3η will have an increasingly important role in the management of RA patients across the entire disease continuum.

List of 14-3-3η EULAR 2018 Conference Proceedings

Decrease in 14-3-3 ETA Protein Levels is Correlated with Improvement of Clinical Disease Activity in Tofacitinib Treated Early Rheumatoid Arthritis Patients
Authors: Ora Shovman, Boris Gilburd, Abdulla Watad, Howard Amital, Pnina Langevitz, Nicola Luigi Bragazzi, Mohammad Adawi, Dolores Pérez, Miri Blank, Norma K. Biln, Anthony Marotta, Yehuda Shoenfeld

Abstract Number: AB0287

14-3-3 ETA Positivity is associated with Higher Rheumatoid Arthritis Disease Activity Measured by Multi-Biomarker Disease Activity Assay
Authors: Robert Chao, Mukund Das, Neha Purat, Petros Efthimiou

Abstract Number: AB0296

Clinical Significance of 14-3-3 ETA Protein Levels in Patients with Rheumatoid Arthritis
Authors: Ora Shovman, Boris Gilburd, Abdulla Watad, Howard  Amital, Pnina Langevitz, Nicola Luigi Bragazzi, Mohammad Adawi, Dolores Pérez, Gil Bornstein , Merav Lidar , Miri Blank, Yosef Azuri, Norma K. Biln, Anthony Marotta, Yehuda Shoenfeld

Abstract Number: FRI0029

Assessment of Serum Levels of 14-3-3 ETA Protein in Rheumatoid Arthritis: Is it a Specific Marker for the Disease?
Authors: Mohsen Elshahaly, May Saleh, Hanaa Fahmy, Marihane Othman

Abstract Number: AB0273

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The 14-3-3η blood test is available in the United States through Labcorp and RDL Reference Laboratory. JOINTstat™ (14-3-3η) is CE marked and TGA approved for clinical use in Europe and Australia. In Canada, the test is available through LifeLabs and in Japan through Medical & Biological Laboratories (MBL).

For more information on the 14-3-3η test and Augurex Life Sciences Corp, visit www.augurex.com or www.jointstat.com.