14-3-3η: How Joint Involvement “Spreads”
14-3-3η: A Critical Mass of Data
A recent systematic literature review describes a substantive body of evidence for 14-3-3η’s clinically important role along the whole continuum of rheumatoid arthritis and autoimmune patient care.
- 14-3-3η helps to assess the veracity of the diagnosis and severity of early RA.
- Can be combined with existing markers to stratify patients to more effective treatments.
- 14-3-3ƞ is a welcome addition for a rheumatologist’s diagnostic and treatment strategy in RA.
Rheumatology and Immunology Research, 2021
How RA Joint Involvement "Spreads"
New findings: 14-3-3η drives joint damage through promoting invadosome formation.
- Consistent with previous findings 14-3-3ƞ is upregulated in a diseased state and is differentially expressed in RA vs OA.
- In RA, fibroblast-like synoviocytes (FLS) are the most common contributors to joint destruction. 14-3-3ƞ drives FLS transformation and contributes dose dependently to joint damage progression.
- 14-3-3ƞ regulates SNAIL production and sequesters FOXO providing new mechanistic insights into the regulation of joint degradation.
International Journal of Molecular Science, 2021