14-3-3η: How Joint Involvement “Spreads”
14-3-3η: A Critical Mass of Data
A recent systematic literature review describes a substantive body of evidence for 14-3-3η’s clinically important role along the whole continuum of rheumatoid arthritis and autoimmune patient care.
Key Statements:
- 14-3-3η helps to assess the veracity of the diagnosis and severity of early RA.
- Can be combined with existing markers to stratify patients to more effective treatments.
- 14-3-3ƞ is a welcome addition for a rheumatologist’s diagnostic and treatment strategy in RA.
Source: The role of 14-3-3 η as a biomarker in rheumatoid arthritis
Rheumatology and Immunology Research, 2021
Rheumatology and Immunology Research, 2021
How RA Joint Involvement "Spreads"
New findings: 14-3-3η drives joint damage through promoting invadosome formation.
Key Findings:
- Consistent with previous findings 14-3-3ƞ is upregulated in a diseased state and is differentially expressed in RA vs OA.
- In RA, fibroblast-like synoviocytes (FLS) are the most common contributors to joint destruction. 14-3-3ƞ drives FLS transformation and contributes dose dependently to joint damage progression.
- 14-3-3ƞ regulates SNAIL production and sequesters FOXO providing new mechanistic insights into the regulation of joint degradation.
Source: 14-3-3η Promotes Invadosome Formation via the FOXO3–Snail Axis in Rheumatoid Arthritis Fibroblast-like Synoviocytes,
International Journal of Molecular Science, 2021
International Journal of Molecular Science, 2021
Arthritis-Health: 14-3-3η Blood Test for diagnosing RA
Arthritis-Health, a trusted publication of Veritas Health which is produced and blind peer-reviewed by licensed health professionals, lists 14-3-3η as the newest biological marker of RA.
For a list of 14-3-3η publications visit our publications page. |
The 14-3-3η Blood Test is Available at:
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